Research to improve the quality of life and reduce the use of traditional drugs, limiting their adverse effects, in conditions of chronic pain
Neuropathic pain is one of the most complex and difficult to treat forms of chronic pain. It originates as peripheral or central nervous system disease or damage and can severely impact quality of life. The neuroinflammatory processes associated with this condition help to modify the sensory pain pathways and make them hypersensitive.
Chronic and neuropathic pain are fueled by neuroinflammation, a protective process in itself, but that in many pathologies tends to be out of control, causing serious dysfunction in the bidirectional transmission between the peripheral and central nervous systems.
Our research into chronic neuropathic pain is exploring new strategies for modulating neuroinflammation and restoring pain circuit homeostasis. In this setting, ALIAmides offer new opportunities for managing complex and sometimes disabling diseases.