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Dermoscience Project

The cutaneous apparatus includes all those physical and cellular mechanisms, present from birth, which act quickly and almost indiscriminate against any external threat.

The skin belongs to the so-called defensive barriers and performs its protective function toward the external pathogens thanks to immune cell populations located in the epidermis and dermis.

In particular, the dermo-epidermal mast cell is considered the skin immunological sensor as well as the cell primarily involved in irritative/inflammatory reactions, pruritogene and pain.

The excessive dermo-epidermal mast cell activation is associated with various sufferings including: seborrheic dermatitis, chronic urticaria, allergic rhinitis, itching and nodularis sine materia.

A new pharmacological modulation of the mast cell, based on specific ALIAmidi responsible for: the muco-cutaneous absorption, the mitigation of irritative/inflammatory cutaneous states, and with a positive effect on itching, pain and swelling.

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