This site uses cookies for technical purposes as specified in the cookie policy.
If you want to learn more or opt out of all or some cookies, see the cookie policy.
By closing the banner or continuing to browse, you consent to the use of cookies.
Scientific Insights
Projects
Ultra-MICRONIZED PALMITOYLETHANOLAMIDE (PEA-um)
Tissue neuroinflammation is a biological process that in pediatric age, due to a neuroimmune immaturity, might turn uncontrolled, and altering the normal development of tissues, among which we the peripheral and central nervous system are found. In pediatric age neuroinflammatory clinical manifestations depend on which body district is getting affected, and predisposing the subject to recurrent respiratory syndromes and dermal-epidermal manifestations (dermatitis with different aetiologies).In these conditions, the body, subjected to recurrent neuroinflammatory phenomena caused by the exposure to multiple factors (viruses, bacteria, allergens, stressful events, hormonal imbalance, etc.), tends to exhaust the synthesis capacity of endogenous Palmitoylethanolamide. Palmitoylethanolamide is a natural compound, found also in breast milk, with strong protective properties and favoring the function of the nervous and immune systems.
The ultramicronized Palmitoylethanolamide (um-PEA), has been shown to control the neuroinflammation of various tissues, including pulmonary and the muco-cutaneous tissues.
Bibliografia
Cerrato S. et al. Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs. The Veterinary Journal. 2012
Costa B. Therapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: inhibition of nitric oxide and cyclo-oxygenase systems. Br J Pharmacol. 2002
Di Paola R. et al. Ultramicronized palmitoylethanolamide (PEA-um®) in the treatment of idiopathic pulmonary fibrosis. Pharmacological Research. 2016
Nestmann ER. Safety of micronized palmitoylethanolamide (microPEA): lack of toxicity and genotoxic potential. Food Sci Nutrition. 2016
Petrosino S. Protective role of palmitoylethanolamide in contact allergic dermatitis. Allergy. 2010
Petrosino S. et al. Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect. Frontiers in Pharma-cology. 2018
Peritore AF. et al. Management of Acute Lung Injury: Palmitoylethanolamide as a New Approach. Int. J. Mol. Sci. 2021
Varricchi G. et al., Physiological Roles of Mast Cells: Collegium Internationale Allergologicum Update 2019. Int Arch Allergy Immunol. 2019
The access to the web site and to its content is only for personal use and purposes (i.e. for personal information, research or study).
Without prejudice to any right, faculty or authority of third parties, in case of prohibited conduct Epitech Group SpA shall reserve the right to act according to the law.