Scientific Insights

Projects

The Hypokinetic Syndrome of the Elder and the Metabolic Syndrome of the Diabetic, constitute growing risk factors - often mutually synergistic - for the onset of an inadequate modulation of low-grade neuroinflammation, destined to progressively alter the balance of the Vascular Neuro-Immuno System. The result are inflammatory algic symptoms, disorders of the musculoskeletal system and, above all, alterations of the autonomic nervous system that stimulate the vessel wall, mainly arterial, that result in functional damage to vessel elasticity and to integrity of its internal wall.
Scientific evidence has shown that the patented and body-usable form of Palmitoylethanolamide (micronized), together with Rutin, acts on both mast cell-dependent low-grade neuroinflammation and elastic vessel reactivity.
Hydroxytyrosol, an active ingredient of olive oil with extraordinary antioxidant power, contributes to determining an adequate control of the circulating lipidic component.

Bibliografia

Aloe L. and Levi-Montalcini R. A proposed autacoid mechanism controlling mastocyte behaviour. Agents Actions. 1993
Fusco R. et al., Micro Composite Palmitoylethanolamide/Rutin Reduces Vascular Injury through Modulation of the Nrf2/HO-1 and NF-kB Pathways. Curr Med Chem. 2021
Impellizzeri D. et al. The neuroprotective effects of micronized PEA (PEA-m) formulation on diabetic peripheral neuropathy in mice. FASEB J. 2019
Peyrol J. et al. Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders. Nutrients. 2017
Rinne P. Palmitoylethanolamide promotes antiinflammatory phenotype of macrophages and attenuates plaque formation in ApoE/mice. Cardiovascular Research Supplements. 2016