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Scientific Insights
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Peripheral and spinal nervous tissue, subjected to recurrent and/or chronic neuroinflammatory conditions of different origin, loses its capacity to synthesize Palmitoylethanolamide, thereby increasing the risk of inflammatory pain and, in cases of injury and/or somatosensory system dysfunction, can result in the gradual transformation of inflammatory pain into neuropathic pain.
In such cases it is of great importance to counteract the activation process of non neuronal cells (not only mast cells at the level of sensory endings and/or endoneural compartment but also microglia at the spinal level) cells who normal act to ensure a homeodynamic balance of nervous tissue.
Scientific evidence has shown that the patented and body-usable form of Palmitoylethanolamide (ultra-micronized) maintains the physiological reactive characteristics of nervous tissue, peripheral and spinal, contributing to the normal functioning of the nociceptive system.
Bibliografia
Aloe L. et al. A proposed autacoid mechanism controllino mastocyte behaviour. Agents Actions.1993
Chirchiglia D. et al. Nonsurgical lumbar radiculopathies treated with ultramicronized palmitoylethanolamide (umPEA): A series of 100 cases. Neurol Neurochir Pol. 2017
Dalla Volta G. et al. Ultramicronized Palmitoylethanolamide Reduces Frequency and Pain Intensity in Migraine: A Pilot Study. J Neurol Brain Dis 2016
Paladini A. et al. Palmitoylethanolamide, a special food for medical purposes, in the treatment of chronic pain: a pooled data meta-analysis. Pain Physician. 2016
Passavanti MB. et al. The beneficial use of ultramicronized palmitoylethanolamide as add-on therapy to Tapentadol in the treatment of low back pain: a pilot study comparing prospective and retrospective observational armso servational arms. BMC Anesthesiol. 2017
Petrosino S. et al. Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect. Frontiers in Pharmacology. 2018
Petrosino S. et al. Palmitoylethanolamide: A Nutritional Approach to Keep Neuroinflammation within Physiological Boundaries. A Systematic Review. Int J Mol Sci. 2020
Skaper SD. et al. Microglia and mast cells: two tracks on the road to neuroinflammation. FASEB J. 2012
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