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Scientific Insights
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Chronic Pelvic Pain associated with several disorders of the pelvic area (e.g. endometriosis, interstitial cystitis, recurrent cystitis, vulvodynia, polycystic ovary syndrome, cyst, etc.) represents a nosological entity with a double localization site, as a consequence of neuroinflammation sustained by non neuronal cells (mast cell, microglia). The tissue localization, linked to the peripheral sensitization occurring to sensory nerves terminals co-innervating different pelvic organs, determines inflammatory diffuse pain entity and the associated oxidative stress. The spinal localization, linked instead to the central sensitization caused by the chronicity of the peripheral neuroinflammation, determines and sustains the neuropathic pain entity that amplifies the algic perception of the Patient.
Scientific evidence has shown that patented and body-usable form of Palmitoylethanolamide (micronized and ultra-micronized) contributes to the normal functioning of the nociceptive system, particularly at the genito-urinary level. Can contribute to normal mood. Polydatin, a polyphenol with high antioxidant activity, allows the control of oxidative stress associated with neuroinflammation in pelvic tissues.
Bibliografia
Cervigni M. et al. Micronized Palmitoylethanolamide-Polydatin Reduces the Painful Symptomatology in Patients with Interstitial Cystitis/Bladder Pain Syndrome. BioMed Research International.2019
Di Paola R. et al. Co-micronized Palmitoylethanolamide/Polydatin Treatment Causes Endometriotic Lesion Regression in a Rodent Model of Surgically Induced Endometriosis. Front Pharmacol. 2016
Indraccolo U. et al. Micronized palmitoylethanolamide/trans-polydatin treatment of endometriosis-related pain:a meta-analysis. Ann Ist Super Sanità. 2017
Indraccolo U. et al. Looking for Responders among Women with Chronic Pelvic Pain Treated with a Comicronized Formulation of Micronized Palmitoylethanolamide and Polydatin. BioMed Research International. 2022
Petrosino S. et al. Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect. Front. Pharmacol. 2018
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