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Disturbances of prostate function, especially involving nervous and fibromuscular tissue, represent a phenowmenon that occurs in urological disorders (benign prostatic hyperplasia and chronic prostatitis) and are sustained primarily by regional neuroinfiammation and localized oxidative stress. At the cellular level the hyperactivity of mast cells, immune cells capable of responding to hormonal, bacterial and traumatic stimuli, is responsible for peripheral sensitization (pelvic pain) and edematous and hyperplastic phenomena which are typical of chronic prostatitis and benign prostatic hyperplasia. The chronicity of peripheral neuroinflammatory processes is strongly influenced by the reactivity of spinal microglia, whose activation amplifies the painful sensations perceived by the patient (central sensitization).
Scientific evidences has shown that patented and body-usable Palmitoylethanolamide (micronized and ultra-micronized) favors a restoration of the physiologically reactive characteristics of prostate tissue as well as normal nervous sensitivity at both the peripheral and spinal levels. This can be attributed to a synergistic and synchronous regulatory effect of micronized and ultramicronized palmitoylethanolamide acting on defined target cells (mast cells and microglia). The potent antioxidant polyphenol polydatin, allows for a focused control of oxidative stress, the latter responsible for amplifying neuroinflammation processes at both the prostate and adjacent pelvic tissue levels.

Bibliografia

Aloe L. et al. A proposed autacoid mechanism controllino mastocyte behaviour. Agents Actions. 1993
Breser ML. et al. Immunological Mechanisms Underlying Chronic Pelvic Pain and Prostate Inflammation in Chronic Pelvic Pain Syndrome. Front Immunol. 2017
Cordaro M. et al. Effects of a co-micronized composite containing palmitoylethanolamide and polydatin in an experimental model of benign pro-static hyperplasia. Toxicol Appl Pharmacol. 2017
Mittino I. et al. Iperplasia prostatica benigna, prostatite cronica e LUTS: ruolo della Palmitoiletanolamide co-micronizzata con Polidatina e ultra-micronizzata nel controllo della sintomatologia. Pelviperineologia. 2021
Paladini A. et al. Palmitoylethanolamide, a special food for medical purposes, in the treatment of chronic pain: a pooled data meta-analysis. Pain Physician. 2016
Petrosino S. et al. Palmitoylethanolamide: A Nutritional Approach to Keep Neuroinflammation within Physiological Boundaries. A Systematic Re-view. Int J Mol Sci. 2020