Scientific Insights


In the developmental age, the harmonious communication between nervous, immune and endocrine systems is fundamental for the functional maturation of the reproductive, urinary and digestive systems of the boy/girl. Anyhow, the functional connectivity between these three systems can be destabilized as a consequence of noxae (hormonal fluctuations, stress, improper diet, etc.) able to hyperactivate the immune cell (the mast cell) which, at pelvic level, promotes the tissue homeostasis. The hyperactive mediators released by the mast cell, acting on the nerve endings localized in the genitourinary and digestive systems, determine oxidative stress and district neuroinflammation, both mechanisms underlying pelvic pain and spasms. These tissue distress mechanisms are recurrent both in the delicate period of sexual maturation of a girl, occurring as primary dysmenorrhea, and in paediatric patients suffering from algic/spastic symptoms in the course of IBS (Irritable Bowel Syndrome).
Under these conditions, it has been shown that the regulatory action exerted by micronized Palmitoylethanolamide on mast cells, through a completely physiological mechanism (ALIA mechanism), in sinergy with the effect on the localized oxidative stress performed by the Polydatin, contributes to the normal functioning of the nociceptive system, particularly at the visceral level.


Peritore AP. et al. PEA/Polydatin: Anti-Inflammatory and Antioxidant Approach to Counteract DNBS-Induced Colitis. Antioxidants (Basel). 2021
Di Nardo G. et al., Palmitoylethanolamide and polydatin in pediatric irritable bowel syndrome: A multicentric randomized control-led trial. Nutrition. 2024
Tartaglia E. et al. Effectiveness of the Association N-Palmitoylethanolamine and Transpolydatin in the Treatment of Primary Dysmenorrhea. J Pediatr Adolesc Gynecol. 2015

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